You said " if a particular segment lets say department is disabled so can we still used a combination".
We cannot disable a segment.
Do you mean to say "if a particular segment value in department segment is disabled"?
In short if you disable a segment value, no new transaction could be "entered" using that values e.g. (journal, invoice, po, pr etc). However that value could still be used in internally generated transactions, e.g. when po is created from pr, when invoice is created from po, when journals are generated from invoice. You will even be able to be post a journal with disabled value.
Disabling a value and disabling combination are two different things.
Disabling combination prevents data entry as well as internal generation of transactions.
E.g., If a combination is disabled then a po cannot be automatically created from pr, invoice cannot be created from po etc.
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